Nicky and John are loyal friends of the Turner family, and John learned to hate Dinklebergs, as well as living in a huge mansion, being insanely rich. Nicky works as a nurse for the Dimmsdale Elementary School, while John works as an exterminator.
Mr. Crocker won the Nobel Peace Prize and doesn't care about fairies. Also, he's muscular and has opened his own gym, being Timmy's gym and school teacher, is much nicer and is married to Geraldine Waxelplax.
A.J. finished college and became the first child President of the United States, with Tad and Chad as his assistants.
Mark Chang is happily married to Princess Mandie, and Boucacians and Yugopotamians have signed a peace treaty with Earth to not destroy it. Also, Princess Mandie is not evil and she is friends with Timmy.
Lauren is still the leader of the B.R.A.T., which targets misbehaving children from miserable families rather than miserable children.
Doidle, Vicky's dog, was never adopted by the Millers and still remains in the pet store somewhere in Dimmsdale.
Trixie Tang is now Timmy's babysitter and girlfriend, and is really nice to him, along with the popular kids, who treat him, Chester and A.J. better.
Interestingly enough, Ivan's alternate life is never shown, and as Jorgen explains, he never flew to Dimmsdale, and stayed in Russia, possibly living a better life.
Although he didn't appear, due to Vicky not being born and Crocker not caring about fairies, it is implied by Jorgen that Francis is responsible for giving the alternate Timmy his fairy godparents.
It's A Wonderful Life - This episode is based on the classic story "It's A Wonderful Life".
Danny Phantom - Amity Park, a city from another Butch Hartman cartoon, Danny Phantom, is mentioned, and A.J. mentions that Tucker Foley shouldn't have been elected to be the mayor, which is what happened in the series finale "Phantom Planet", and instead wants someone more competent to be elected as the city's mayor, mirroring some of the fans' complaints about "Phantom Planet".