Chemo-Clown commits crimes with countless "comedic" weapons (such as razor-sharp playing cards, acid flowers and lethal electric joy buzzers), including "happy gas" a poison that infects his victims with a ghoulish rictus grin as they lose consciousness while laughing uncontrollably, but Chemo-Clown himself is immune to his "happy gas". Chemo-Clown is a genius at planning and improvising criminal activities. He is incredibly intelligent and calculating, always staying one step ahead of everyone else, including Cleft and the Crimson Chin.
Chemo-Clown is similar to Batman's archenemy, the Joker. Chemo-Clown's personality is similar to the Joker's counterpart from the 2008 movie the Dark Knight, portrayed by the late Heath Ledger.